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Short-term toxicity to aquatic invertebrates

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Description of key information

Short term toxicity test was predicted in Daphnia magna for 48 hrs in static condition using freshwater followed OECD guideline 202.Based on the study the EC 50 value for 4-amino-5-hydroxynaphthalene-1,7-disulphonic acid was predicted to be 133.610977173 mg/l. 
According to the CLP regulations the chemical was categories as not classified.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
133.611 mg/L

Additional information

Various predicted studies for the target chemical 4-amino-5-hydroxynaphthalene-1, 7-disulphonic acid were reviewed to summarize the following information: 

48 hrs aquatic toxicity study (EPI suite, 2016) was conducted to assess toxic effects of the test compound 4-amino-5-hydroxynaphthalene-1, 7-disulphonic acid (CAS no 130-23-4) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-amino-5-hydroxynaphthalene-1, 7-disulphonic acid was estimated to be778000 mg/lon the basis of mobility.

 

48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound 4-amino-5-hydroxynaphthalene-1, 7-disulphonic acid (CAS no 130-23-4) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-amino-5-hydroxynaphthalene-1, 7-disulphonic acid (CAS no 130-23-4) was estimated to be 133.610977173 mg/L on the basis of mobility. 

  

On the basis of results of various predictions for toxicity to aquatic algae and cyanobacteria, it can be considered that the substance is not likely to be toxic to aquatic invertebrates at environmentally relevant concentrations and can be classified as non- hazardous as per the criteria of CLP regulation.