Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline Study with detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
MAEEBP
IUPAC Name:
MAEEBP
Constituent 2
Chemical structure
Reference substance name:
2-[2-(4-benzoylphenoxy)ethoxy]ethyl methacrylate
EC Number:
943-359-7
Molecular formula:
C21H22O5
IUPAC Name:
2-[2-(4-benzoylphenoxy)ethoxy]ethyl methacrylate
Details on test material:
- Name of test material (as cited in study report): MAEEBP- Physical state: colourless liquid- Composition of test material, percentage of components: 4-methacryloyl diethoxy benzophenone 85 area%, impurities 4-hydroxybenzophenone <5%, 4-methacryloyl benzophenone <5%, polymethacrylate <5%- Lot/batch No.: 150301- Expiration date of the lot/batch: Sep. 2015- Storage condition of test material: The test item was stored in the test facility in a closed vessel in the refrigerator (2-8°C) protected from light and humidity (exception: 22.- 28. Apr. 2015 storage at room temperature).

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
2.707
Temp.:
25 °C
Remarks on result:
other: Peak 1
Type:
log Pow
Partition coefficient:
3.708
Temp.:
25 °C
Remarks on result:
other: Peak 2

Any other information on results incl. tables

The QSAR software program KOWWIN 1.68 (US EPA 2012 Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10. United States Environmental Protection Agency, Washington, DC, USA) gave an estimated log POW of 3.89.

Result of HPLC determination:

As peak 1 showed a relative area 5 %, this peak was considered as minor peak. Although area is not necessarily correlated to absolute concentration if a UV detector is used, it is assumed that the test item consists mainly of peak 2. Using the correlation log K / log POW, the log POW of the major component of test item MAEEBP was calculated as 3.708 ± 0.001 (mean ± standard deviation).

Applicant's summary and conclusion

Conclusions:
The log POW of MAEEBP was determined using the HPLC method according to OECD 117 resp. EU A.8. The partitioning coefficient for the major component of test item MAEEBP was calculated as 3.708.

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