2-methylpyridine

PBT assessment

PBT assessment: overall result

PBT status:

the substance is not PBT / vPvB

Justification:

Type of Data	PBT-Criterion	vPvB-Criterion	Value for	Conclusion
Persistence
Ready Biodegradability test	Not readily	Not readily	Readily biodegradable	Not P, not vP
Inherent Biodegradability	t1/2> 60 days in marine water, or
	t1/2> 40 days in fresh or estuarine water, or	t1/2> 60 days in marine, fresh- or estuarine water, or
	t1/2> 180 days in marine sediment, or	t1/2> 180 days in marine, fresh- or estuarine sediment, or
	t1/2> 120 days in soil	t1/2> 180 days in soil
Abiotic degradation
Photodegradation
Bioaccumulation
Evidence of biomagnification	BCF > 2000 L/kg	BCF > 5000 L/kg	Predicted BCF =2.508 L/kg	Not B, not vB
Octanol-water partition coefficient (screening)	Log Kow≥ 4.5	Log Kow≥ 4.5	Log Kow= 1.11	Not B, not vB
Toxicity
	NOEC (long-term) < 0.01 mg/L, or		Short term LC50 > 100 mg/L	Not T
	Classification as carcinogenic (category 1A or B) , germ cell mutagenic (category 1 or 1B) or toxic for reproduction (category 1A, 1B or 2) according to the CLP Regulation, or		Not CMR	Not T
	Evidence of chronic toxicity and classification as specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to the CLP Regulation.		No evidence of chronic toxicity	Not T

Detailed information regarding the PBT/vPvB determination is summarised in the table (above). The substance has been shown to be readily biodegradable and therefore is not persistent. The substance has an octanol-water partition coefficient (log Kow) of 1.11, substantially below the screening criterion of 4.5, above which a substance may be considered to be bioaccumulative and very bioaccumulative; the substance has a predicted BCF of 2.508 L/kg, substantially below both the definitive BCF thresholds of 2000 L/kg for bioaccumulative and 5000 L/kg for very bioaccumulative. This substance does not meet the screening criteria for aquatic toxicity, as the lowest short-term L(E)C₅₀value of 320 mg/L is substantially above the definitive criterion of L(E)C₅₀< 0.01 mg/L and the screening criterion of L(E)C₅₀< 0.1 mg/L for aquatic toxicity. The substance does not meet any of the criteria for mammalian toxicity in accordance with the CLP Regulation, i.e., carcinogenic (category 1A or 1B), mutagenic (category 1 or 1B), toxic for reproduction (category 1A, 1B or 2), or other evidence of chronic toxicity, i.e., specific target organ toxicity after repeated exposure (STOT RE category 1 or 2). Thus, the substance has been determined to be not persistent, not bioaccumulative and not toxic, and is considered to be not PBT and not vPvB.