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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on developmental toxicity

Description of key information
Maternal toxicity NOAEC and fetal toxicity NOAEC (10 days) > 4.9 ppm (6.96 mg/m3)
Maternal LOAEL = 7 ppm (9.94 mg/m3)
Effect on developmental toxicity: via inhalation route
Dose descriptor:
6.96 mg/m³
Additional information

Groups of 24 pregnant F344 rats were exposed to 0, 0.033, 2.8, 4.9, or 7 ppm of phosphine for 6 h/day during days 6-15 of gestation. Fourteen females exposed to 7 ppm died after 3-10 days of exposure (Newton, 1993).

No maternal deaths were observed at lower concentrations, suggesting a steep concentration response with regard to lethality. Due to excessive the mortality, the remaining animals in the 7 ppm group were terminated.

No adverse treatment-related effects were observed in maternal body weight and feed consumption, maternal physical observations, or uterine implantation. No treatment-related effects were observed during maternal postmortem examinations. No treatment-related effects were observed on mean fetal weights or fetal sex ratio.

Justification for classification or non-classification

Phosphine is listed on Annex VI to Regulation (EC) No 1272/2008 includes lists of harmonised classification and labelling. No change is proposed for these effects.

Additional information