Registration Dossier
Registration Dossier
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EC number: 232-260-8 | CAS number: 7803-51-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
Maternal toxicity NOAEC and fetal toxicity NOAEC (10 days) > 4.9 ppm (6.96 mg/m3)
Maternal LOAEL = 7 ppm (9.94 mg/m3)
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- NOAEC
- 6.96 mg/m³
Additional information
Groups of 24 pregnant F344 rats were exposed to 0, 0.033, 2.8, 4.9, or 7 ppm of phosphine for 6 h/day during days 6-15 of gestation. Fourteen females exposed to 7 ppm died after 3-10 days of exposure (Newton, 1993).
No maternal deaths were observed at lower concentrations, suggesting a steep concentration response with regard to lethality. Due to excessive the mortality, the remaining animals in the 7 ppm group were terminated.
No adverse treatment-related effects were observed in maternal body weight and feed consumption, maternal physical observations, or uterine implantation. No treatment-related effects were observed during maternal postmortem examinations. No treatment-related effects were observed on mean fetal weights or fetal sex ratio.
Justification for classification or non-classification
Phosphine is listed on Annex VI to Regulation (EC) No 1272/2008 includes lists of harmonised classification and labelling. No change is proposed for these effects.
Additional information
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