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Diss Factsheets
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EC number: 200-929-3 | CAS number: 76-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is well conducted for its purpose. It gives some information regarding distribution of the test substance but due to the nature of the work (research), no guideline followed and only few tissues were examined.
Data source
Reference
- Reference Type:
- publication
- Title:
- Distribution of Halothane and the Metabolites Trifluoroacetic Acid and Bromide in the Conceptus after Halothane Inhalation by Pregnant Mice
- Author:
- Ghantous H et al.
- Year:
- 1 986
- Bibliographic source:
- Acta pharmacol. et toxicol. 59, 370-376
- Report date:
- 1986
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Trifluoroacetic acid (which is a metabolite of halothane) and halothane were tested in the study in parallel. Trifluoroacetic acid was administered to pregnant mice by intravenous injection and the plasma and amniotic fluid were collected for the analysis. In parallel halothane was administered to pregnant mice by inhalation route for 1 hour. Subsequently, the mice were killed and blood and amniotic fluid were collected for the analysis of distribution of halothane in fetuses and in body fluids.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- mouse
- Strain:
- C57BL
- Sex:
- female
Administration / exposure
- Route of administration:
- other: Inhalation for Halothane, intravenously for TFA
- Vehicle:
- other: saline solution for TFA
- Duration and frequency of treatment / exposure:
- single dose (TFA)
single dose for 1 hour (halothane)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 µmol (TFA)
- No. of animals per sex per dose / concentration:
- 8 mice pregnant on day 18 of gestation
- Control animals:
- no
Results and discussion
- Preliminary studies:
- no
Main ADME results
- Type:
- other: Distribution and accumulation
- Results:
- Trifluoroacetic acid (TFA) was accumulated and retained in amniotic fluid after exposure of preganant mice with Halothane or after infusion in maternal blood with TFA.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- not applicable
- Details on distribution in tissues:
- The concentration of halothane in maternal plasma decreased rapidly. In the amniotic fluid the halothane never reached more than 20 % of maternal plasma levels. Trifluoroacetic acid (TFA), formed mainly by maternal metabolism of halothane, accumulated in foetus and amniotic fluid with time, and reached plateau levels in amniotic fluid between 4 and 24 hrs. TFA infused intravenously to the mother reached higher levels in amniotic fluid after long survival times than in maternal plasma.
Transfer into organsopen allclose all
- Test no.:
- #1
- Transfer type:
- blood/placenta barrier
- Observation:
- slight transfer
- Remarks:
- after inhalation exposure halothane appeared in the conceptus but 4 hours after the end of exposure the concentration of halothane in maternal blood and amniotic blood was very low or null.
- Test no.:
- #2
- Transfer type:
- blood/placenta barrier
- Observation:
- distinct transfer
- Remarks:
- TFA was accumulated and retained in amniotic fluid after inhalation exposure of pregnant mice with halothane or after infusion in maternal blood with TFA. TFA is mainly formed by maternal metabolism
- Details on excretion:
- not applicable
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- TFA is formed as a result of halothane metabolism (mainly maternal metabolism)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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