Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: A secondary literature only
Data source
Referenceopen allclose all
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- ECHA disseminated dossier
- Year:
- 2 014
- Bibliographic source:
- ECHA disseminated dossier
- Report date:
- 2014
- Reference Type:
- secondary source
- Title:
- not applicable
- Author:
- not applicable
- Year:
- 2 008
- Bibliographic source:
- GESTIS-database on hazardous substances - Information system on hazardous substances of the German Social Accident Insurance
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Remarks:
- due to the minimum information given
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Not indicated precisely. Only from the results one can assume that at least the following concentrations were used: 250 mg/kg bw and 1000 mg/kg bw
- No. of animals per sex per dose:
- 90 rats in the study. Number of animals per sex per dose not indicated.
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 250 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- other: LD10
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
In the clinical picture, breathing disturbances similar to those that occur in acute inhalation poisoning are observed. In individual animals the motor activity is intensified immediately after administration of the substance, although the animals display less movement and motor activity more often. Varying degrees of haemorrhaging and necrosis in the mucous membranes of the stomach, dystrophic changes in the liver, kidneys and brain were detected in macro-and micro-investigations of organ of dead rats.
Applicant's summary and conclusion
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