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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The Effects of Terpenoids and other olized Dietary Anutrients on Hepatic Drug-Metabolizing Enzymes
Author:
Parke DV and Rahman H
Year:
1969
Bibliographic source:
Biochem J 113 (2): 12
Reference Type:
secondary source
Title:
The Effects of Terpenoids and other olized Dietary Anutrients on Hepatic Drug-Metabolizing Enzymes
Author:
Parke DV and Rahman H
Year:
1969
Bibliographic source:
Report to RIFM (Location 1841 )

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
The study was conducted to investigate the effect of the test material on the activities of the hepatic drug metabolizing enzymes.
GLP compliance:
no
Remarks:
; GLP was not compulsory at the time the study was conducted.

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
EC Number:
230-597-5
EC Name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
Cas Number:
7212-44-4
Molecular formula:
C15H26O
IUPAC Name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol
Details on test material:
- Name of test material (as cited in study report): Nerolidol, isomers unknown
- Analytical purity: no data given
Radiolabelling:
no

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: oral feed or i.v.
Vehicle:
not specified
Details on exposure:
Rats were pretreated for 3 days with nerolidol administered by intraperitoneal injection or by admixture with their food.
Duration and frequency of treatment / exposure:
3 days
Doses / concentrations
Remarks:
Doses / Concentrations:
no data given
No. of animals per sex per dose / concentration:
no data given
Control animals:
not specified
Details on study design:
Biphenyl 4-hydroxylase, glucuronyl transferase and 4-nitrobenzoate reductase activities and cytochrome P-450 were determined in 10000g supernatants of the liver homogenates.

Results and discussion

Preliminary studies:
no data given

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data given
Details on distribution in tissues:
no data given
Details on excretion:
no data given

Metabolite characterisation studies

Metabolites identified:
no
Details on metabolites:
The authors stated that the test material is metabolized by reduction and conjugation with glucuronic acid

Applicant's summary and conclusion