Registration Dossier
Registration Dossier
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EC number: 230-597-5 | CAS number: 7212-44-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Effects of Terpenoids and other olized Dietary Anutrients on Hepatic Drug-Metabolizing Enzymes
- Author:
- Parke DV and Rahman H
- Year:
- 1 969
- Bibliographic source:
- Biochem J 113 (2): 12
- Reference Type:
- secondary source
- Title:
- The Effects of Terpenoids and other olized Dietary Anutrients on Hepatic Drug-Metabolizing Enzymes
- Author:
- Parke DV and Rahman H
- Year:
- 1 969
- Bibliographic source:
- Report to RIFM (Location 1841 )
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- The study was conducted to investigate the effect of the test material on the activities of the hepatic drug metabolizing enzymes.
- GLP compliance:
- no
- Remarks:
- ; GLP was not compulsory at the time the study was conducted.
Test material
- Reference substance name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- EC Number:
- 230-597-5
- EC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- Cas Number:
- 7212-44-4
- Molecular formula:
- C15H26O
- IUPAC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Nerolidol, isomers unknown
- Analytical purity: no data given
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral feed or i.v.
- Vehicle:
- not specified
- Details on exposure:
- Rats were pretreated for 3 days with nerolidol administered by intraperitoneal injection or by admixture with their food.
- Duration and frequency of treatment / exposure:
- 3 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data given
- No. of animals per sex per dose / concentration:
- no data given
- Control animals:
- not specified
- Details on study design:
- Biphenyl 4-hydroxylase, glucuronyl transferase and 4-nitrobenzoate reductase activities and cytochrome P-450 were determined in 10000g supernatants of the liver homogenates.
Results and discussion
- Preliminary studies:
- no data given
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data given
- Details on distribution in tissues:
- no data given
- Details on excretion:
- no data given
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- The authors stated that the test material is metabolized by reduction and conjugation with glucuronic acid
Applicant's summary and conclusion
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