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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral and dermal toxicity studies
Author:
Russell TJ
Year:
1973
Bibliographic source:
Report to RIFM (Location 2033, Sub-Reference 03/06); cited in: Opdyke DLJ (1975): Monographs on Fragrance Raw Materials. Food Cosmet Toxicol 13: 887

Materials and methods

Principles of method if other than guideline:
No data given.
GLP compliance:
not specified
Test type:
other: no data given

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
EC Number:
230-597-5
EC Name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
Cas Number:
7212-44-4
Molecular formula:
C15H26O
IUPAC Name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol
Details on test material:
- Name of test material (as cited in study report): Nerolidol
- Analytical purity and isomere specification: no data given

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
No data given.
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
Observation period lasted 14 days. The animals were observed for moratlity and clinical signs of toxicity.

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
No deaths occured.
Clinical signs:
No effects were seen.

Applicant's summary and conclusion