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EC number: 230-597-5 | CAS number: 7212-44-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute oral and dermal toxicity studies
- Author:
- Russell TJ
- Year:
- 1 973
- Bibliographic source:
- Report to RIFM (Location 2033, Sub-Reference 03/06); cited in: Opdyke DLJ (1975): Monographs on Fragrance Raw Materials. Food Cosmet Toxicol 13: 887
Materials and methods
- Principles of method if other than guideline:
- No data given.
- GLP compliance:
- not specified
- Test type:
- other: no data given
Test material
- Reference substance name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- EC Number:
- 230-597-5
- EC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- Cas Number:
- 7212-44-4
- Molecular formula:
- C15H26O
- IUPAC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Nerolidol
- Analytical purity and isomere specification: no data given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- No data given.
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- Observation period lasted 14 days. The animals were observed for moratlity and clinical signs of toxicity.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No deaths occured.
- Clinical signs:
- No effects were seen.
Applicant's summary and conclusion
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