Reaction mass of sodium prop-2-enesulphonate and sodium chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline with acceptable restrictions (mostly due to reduced reporting in times before GLP)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium prop-2-enesulphonate

EC Number:

219-676-5

EC Name:

Sodium prop-2-enesulphonate

Cas Number:

2495-39-8

Molecular formula:

C3H6O3S.Na

IUPAC Name:

sodium prop-2-ene-1-sulfonate

Details on test material:

- Name of test-item: Golpanol SC 9269 = Golpanol ALS
- Batch identification: 04749356P0
- Purity: 25 % in aqua dest.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gassner
- Mean weight at study initiation: 180 g (male), 160 g (female)

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: dest. water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 25 %
- Amount of vehicle (if gavage): 10000 µl/kg

MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw

Doses:

100, 1000, 10000 µl/kg

No. of animals per sex per dose:

5 for the highest dose
2 females for the other doses

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing was prior the beginning of the study for dose calculation, on day 3, 7 and 13. Observation of clinical signs was several times on the day of administration and once daily afterwards with exception of weekends.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 mL/kg bw

Based on:

test mat.

Remarks on result:

other: 1/10 animals died at the highest dose tested

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 1/10 animals died. at the highest dose tested (ca. 12300 mg/kg bw)

Mortality:

1/10 animals died one day after application of 10000 µl/kg bw. No mortality was observed in the other dose groups.

Clinical signs:

other: Sporadic dyspnoea, apathy and diarrhoea the first hours after administration of the test substance at the highest dose level.

Gross pathology:

Sporadic pneumotic areals in lungs were noted in the animals examined at termination of the study.