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EC number: 212-112-9 | CAS number: 763-69-9
The cause of deaths in three female rats was not evident from the pathology data, but there was no evidence of significant organ damage after extensive tissue analysis. This finding is consistent with deaths caused by anesthesia following exposure to high levels of solvents. There was no evidence of specific neurotoxicity following examination of the brain, spinal cord, peripheral nerves, dorsal root ganglia, skeletal muscle, and neural tissue present in visceral organs.
A single dose of 5000 mg/kg bw was administered to rats by oral gavage. None of the male rats died at this dose level and the LD50 for male rats can be established to be greater than 5000 mg/kg bw.
For female rats 3/5 died at 5000 mg/kg bw. However, in a previous study (see TX 83 -70) dose levels of 1600 and 3200 mg/kg bw were administered to female rats and 0/4 animals died at both dose levels. Based on the results of the two studies and LD50 of 4309 mg/kg bw was calculated for female rats.
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