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Diss Factsheets
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EC number: 259-370-9 | CAS number: 54839-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1954
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given; similar to guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology of mono-, di- and tri-propylene glycol methyl ethers
- Author:
- Rowe VK, McCollister DD, Spencer HC, Oyen F, Hollingsworth RL, and Drill VA
- Year:
- 1 954
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med 9:509-525
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see below
- Principles of method if other than guideline:
- Method used was essentially that of Draize JH, Woodard G and Calvery HO. (1944) Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol & Exper Therap. 82: 377-390.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methoxypropan-2-ol
- EC Number:
- 203-539-1
- EC Name:
- 1-methoxypropan-2-ol
- Cas Number:
- 107-98-2
- IUPAC Name:
- 1-methoxypropan-2-ol
- Details on test material:
- 1-methoxypropan-2-ol is a close structural analogue of 1-ethoxypropan-2-ol, which is the major hydrolysis product of the submission substance (1-ethoxypropan-2-yl acetate).
- Name of test material (as cited in study report): Propylene glycol methyl ether
- Molecular formula (if other than submission substance):
- Molecular weight (if other than submission substance):
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state:
- Analytical purity: essentially 100%
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.:
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions:
- Storage condition of test material:
- Other:
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: impervious sleeves covered by heavy cloth bandages
REMOVAL OF TEST SUBSTANCE
- Washing (if done): cleansed with soap and water
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- 5.0, 7.0 10.0, 12.0 or 15.0 ml/kg
- No. of animals per sex per dose:
- 5 or 10 animals per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: two weeks, or until it was certain that they had recovered from effects.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- 13.42 mL/kg bw
- Based on:
- test mat.
- Mortality:
- Deaths occurred within one to five days.
- Clinical signs:
- Within a few hours after dosing the animals exhibited symptoms of general narcosis varying in intensity from slight weakness and drowsiness to deep anesthesia. At the lower dosage levels, recovery from this narcotic effect was usually complete within 24 hours, but with the higher dosages recovery was prolonged, sometimes for several days.
- Body weight:
- All dosages caused some loss in body weight. Recovery from this response was rapid at doses of less than 10 ml per kg, but was usually prolonged for several days at the higher dosage levels.
Any other information on results incl. tables
For the purposes of risk assessment, a LOEL of 7ml/kg was defined by the submitter from this study (mild transient effects only). This is equivalent to
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
Based on an early acute dermal toxicity study in rabbits, the single dose LD50 for methoxypropanol (a close structural analogue of the hydrolysis product of ethoxypropyl acetate) applied to the occluded skin for 24-hours is estimated to be 13.42 ml/kg (12.33g/kg) which is equivalent on a molar basis to 20.0g/kg. This data comes from an old study but the available information in the study publication suggest that the data can be considered a reliable indicator of the acute dermal toxicity of this substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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