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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 5, 2016
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 105 (Water Solubility)
GLP compliance:
Type of method:
flask method
Water solubility:
ca. 143.77 g/L
Conc. based on:
test mat.
20 °C
Remarks on result:
other: pH mother solution = 6.60; pH satured solution = 8.15
Details on results:
Reference samples and extract were first measured in the range 190 / 800 nm, so as to choose the right wavelength for quantitative measurements.Since absorbance of the test solution kept the same proportions along the UV and visible spectra, preliminary test result was considered for the final results calculations. Wavelength chosen was 454.50 nm. Reference solutions were measured in the spectrophotometer in quantitative mode, thus generating a calibration curve. Calibration curve was smooth and linear at every concentration. Considering that preliminary test resulted in an absorbance keeping the same shape like the references, its value was considered for the 24 hours’ measurement (test 1). Adjusting concentrations in proportion to the real weights the following results were obtained:
-Test 1 (24 hs): 142.08 g/
-Test 2 (48 hs): 142.71 g/l
-Test 3 (96 hs): 146.54 g/l
The average water solubility value is 143.77 g/l at 20 °C and pH= 8.15.
Executive summary:


Solubility was performed following the recommendations of the OECD Method 105.


Average solubility: 143.77 g/l at 20 °C and pH 8.15 satured solution.

Description of key information

143.77 g/l at 20 °C at pH 8.15

Key value for chemical safety assessment

Water solubility:
143.77 g/L
at the temperature of:
20 °C

Additional information

Water solubility test was carried out according to the OECD Guideline 105. The average value is 143.77 g/l at 20 °C at pH 8.15