Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 277-381-7 | CAS number: 73324-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From August 03 to 23, 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The test was conducted by means of Read Across approach. The reliability of the source study report is 1. Further information was attached at section 13
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Acute Toxicity Test for Freshwater Invertebrates, EPA- 540/9-85-005, June, 1985.
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples with a nominal concentration of 100 mg/l of the substance were diluted 10 fold with test medium prior to the analysis. The stock solution of the biological test was diluted 40 fold with test medium. All other samples were analysed by VIS-spectroscopy without any dilution.
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Source: bred in the laboratories of RCC under standardized conditions
- Age at study initiation: (6-24 hours old)
- Feeding during test: NO
- Method of breeding: standardized conditions
ACCLIMATION
- Acclimation period:24 hours
- Temperature: 18-22 °C with a max. deviation of ± 1 °C during the experiment - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 2.5 mmol/l as CaCO3
- Test temperature:
- 19.0 - 20.5 °C
- pH:
- 7.9
- Dissolved oxygen:
- 8.5 ± 0.2 mgO2/l
- Nominal and measured concentrations:
- nominal test concentrations: 15.6, 62.5 and 250 mg test article/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 ml glass baker
- Type: closed
- Material, size, headspace, fill volume: 50 ml
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration: 4
- No. of vessels per control: 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
CaCl2 x 2H20 294 mg/l
MgSO* x 7H20 123 mg/l
NaHCO3 65 mg/l
KCl 5.8 mg/l
- Alkalinity: 0.8 mmol/l
- Ratio Ca: Mg ratio: 4:1
- Ratio Na: K ratio: 10:1
- Conductivity: < 0.1 µs/cm
OTHER TEST CONDITIONS
- Adjustment of pH: yes, if necessary , the pH of the test medium samples for the analyses will be adjusted to pH 3-4 with hydrochloric acid
- Photoperiod: 16 hours/day
- Light intensity: 200 - 600 Lux - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- < 15 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 55 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 38.5 to 78.6 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- ca. 250 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 (48h) = 55 mg/l
- Executive summary:
The acute toxicity to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adopted 4 April 84, the EEC Directive 84/449, L 251, Part C 2, and to the Guideline of the U.S. Environmental Protection Agency, Pesticide Assessment Guidelines, Subdivision E, EPA-540/9-85-005, June, 1985.
The test was performed in compliance with the Good Laboratory Practice Regulations. The nominal concentrations tested was 15.6, 31.3, 62.5, 125 and 250 mg test article/l and a control without any additions.
Test results:
24h EC 0: 31.3 mg test article/l
24h EC 50: 164.9 mg test article/l (95 % conf. limits 143.6 - 189.5 mg test article/l)
24h EC 100: 250.0 mg test article/l
48h EC 0 < 15.6 mg test article/l
48h EC 50: 55.0 mg test article/l (95 % Conf. limits: 38.5 - 78.6 mg test article/l)
48h EC 100: 250.0 mg test article/l
All reported results are related to nominal concentrations of the test article. During test duration the active ingredient concentrations were in the range of 102.6 - 110.6 % of the nominal values, under test conditions the test article was sufficiently stable.
Reference
Description of key information
EC50(48h) = 55 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 55 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.