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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
biochemical or cellular interactions
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Exploratory study

Data source

Referenceopen allclose all

Title:
No information
Author:
also cited in OECD SIDS Dossier Imidazole, Final August 2005
Title:
No information
Author:
Ritter JK, Franklin MR (1987) Induction of hepatic oxidative|and conjugative drug metabolism in the hamster by|N-substituted imidazoles. Toxicology Letters 36: 51-59

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Imidazole
EC Number:
206-019-2
EC Name:
Imidazole
Cas Number:
288-32-4
Molecular formula:
C3H4N2
IUPAC Name:
1H-imidazole
Details on test material:
TS-Freetext:
Imidazole from Eastman Kodak, unspecified degree of purity

Results and discussion

Any other information on results incl. tables

RS-Freetext:
No statistically significant changes noted compared to the
control animal groups in either sex in any of the parameters
exempt a 30% decrease of ethylmorphine demethylation in
females.

Applicant's summary and conclusion

Conclusions:
CL-Freetext:
Treatment of Syrian golden hamsters with imidazole did not
influence liver weight and liver phase I and phase II drug
metabolism enzymes.

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