Registration Dossier
Registration Dossier
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EC number: 206-019-2 | CAS number: 288-32-4
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Exploratory study
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- also cited in OECD SIDS Dossier Imidazole, Final August 2005
- Title:
- No information
- Author:
- Ritter JK, Franklin MR (1987) Induction of hepatic oxidative|and conjugative drug metabolism in the hamster by|N-substituted imidazoles. Toxicology Letters 36: 51-59
Materials and methods
Test material
- Reference substance name:
- Imidazole
- EC Number:
- 206-019-2
- EC Name:
- Imidazole
- Cas Number:
- 288-32-4
- Molecular formula:
- C3H4N2
- IUPAC Name:
- 1H-imidazole
- Details on test material:
- TS-Freetext:
Imidazole from Eastman Kodak, unspecified degree of purity
Constituent 1
Results and discussion
Any other information on results incl. tables
RS-Freetext:
No statistically significant changes noted compared to the
control animal groups in either sex in any of the parameters
exempt a 30% decrease of ethylmorphine demethylation in
females.
Applicant's summary and conclusion
- Conclusions:
- CL-Freetext:
Treatment of Syrian golden hamsters with imidazole did not
influence liver weight and liver phase I and phase II drug
metabolism enzymes.
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