Registration Dossier
Registration Dossier
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EC number: 200-890-2 | CAS number: 75-66-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- This study was classified as reliable with restrictions because the test procedure was in acc ordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US DoT guideline no. 49 CFR 173.240
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylpropane-2-thiol (CAS # 75-66-1)
- IUPAC Name:
- 2-methylpropane-2-thiol (CAS # 75-66-1)
- Details on test material:
- Source: Pennwalt Corporation
Batch: 803-TBM-76
Purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritant effects of any kind were discernible at any of the treated skin sites.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a skin irritation and corrosion study, 2-methylpropane-2-thiol was found to be not irritating.
- Executive summary:
In a skin irritiation and corrosion study (49 CFR 173.240), six albino rabbits (sex and strain unspecified) received 0.5mL of undiluted 2 -methylpropane-2-thiol (CAS # 75 -66 -1) applied to the intact skin site under standard gauze patches. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. No signs of
irritation were discernible at any of the six treated skin sites. The substance was classified as not irritating based on EC Regulation No 1272.
This study received a Klimisch score of 2 and was classified as reliable with restrictions because the test procedure was in accordance with national standard methods with acceptable restrictions.
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