4-chlorobenzaldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-chlorobenzaldehyde

EC Number:

203-247-4

EC Name:

4-chlorobenzaldehyde

Cas Number:

104-88-1

Molecular formula:

C7H5ClO

IUPAC Name:

4-chlorobenzaldehyde

Details on test material:

- purity: 99 %

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: obtained from breeder Winkelmann
- Weight at study initiation: 160 - 180 g
- Housing: 5 animals per caqge, SPF

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Lutrol

Doses:

600, 700, 800, 900, 1000 or 1200 mg/kg bw

No. of animals per sex per dose:

- 10 male rats per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

LD50 was calculated according to Fink an dHund, Arzneim.-Forsch. 15, 624 (1965).

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

840 mg/kg bw

Based on:

test mat.

95% CL:

780 - 910

Mortality:

see "any other information on results incl. tables"

Clinical signs:

other: All animals receiving more than 600 mg/kg bw showed clinical symptoms. The symptoms included poor general state, diarrhoea, bloody nose, sedation or epistaxis.

Gross pathology:

no data

Other findings:

see table below

Any other information on results incl. tables

Mortality:

Dose [mg/kg bw]	Time of death	dead animals	animals with symptoms	treated animals
600	-	0	0	10
700	3 h	3	10	10
800	2 d	3	10	10
900	2 d	5	10	10
1000	2 d	9	10	10
1200	3 h	10	10	10

Applicant's summary and conclusion

Executive summary:

In a acute oral toxicity study (Bayer AG, Department of Toxicology, 1979), groups of young adult Wistar rats (10 males per group) were given a single oral dose of  p-Chlorobenzaldehyde (99 % a.i.) in Lutrol at doses of  600, 700, 800, 900, 1000 or  1200  mg/kg bw and observed for 14 days.

 

The oral LD₅₀ value was established to be 840 mg/kg bw.