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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorobenzaldehyde
EC Number:
203-247-4
EC Name:
4-chlorobenzaldehyde
Cas Number:
104-88-1
Molecular formula:
C7H5ClO
IUPAC Name:
4-chlorobenzaldehyde
Details on test material:
- purity: 99 %

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: obtained from breeder Winkelmann
- Weight at study initiation: 160 - 180 g
- Housing: 5 animals per caqge, SPF

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Lutrol
Doses:
600, 700, 800, 900, 1000 or 1200 mg/kg bw
No. of animals per sex per dose:
- 10 male rats per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
LD50 was calculated according to Fink an dHund, Arzneim.-Forsch. 15, 624 (1965).

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
840 mg/kg bw
Based on:
test mat.
95% CL:
780 - 910
Mortality:
see "any other information on results incl. tables"
Clinical signs:
other: All animals receiving more than 600 mg/kg bw showed clinical symptoms. The symptoms included poor general state, diarrhoea, bloody nose, sedation or epistaxis.
Gross pathology:
no data
Other findings:
see table below

Any other information on results incl. tables

Mortality:

Dose

[mg/kg bw]

Time of death

dead animals

animals with symptoms

treated animals

 

 

 

 

 

600

-

0

0

10

700

3 h

3

10

10

800

2 d

3

10

10

900

2 d

5

10

10

1000

2 d

9

10

10

1200

3 h

10

10

10

Applicant's summary and conclusion

Executive summary:

In a acute oral toxicity study (Bayer AG, Department of Toxicology, 1979), groups of young adult Wistar rats (10 males per group) were given a single oral dose of  p-Chlorobenzaldehyde (99 % a.i.) in Lutrol at doses of  600, 700, 800, 900, 1000 or  1200  mg/kg bw and observed for 14 days.

 

The oral LD50 value was established to be 840 mg/kg bw.