4-(2-aminoethyl)phenol

Endpoint summary

Link to relevant study record(s)

Reference

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from hand book

Objective of study:

absorption

distribution

metabolism

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

In vivo Absorption, Distribution and Metabolism study of 4-(2-aminoethyl)phenol in human

GLP compliance:

not specified

Specific details on test material used for the study:

Name: 4-(2-Aminoethyl)phenol
SMILES:NCCc1ccc(O)cc1
InChI:1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
Mol. formula: C8H11NO
Molecular Weight: 137.1809 g/mole

Radiolabelling:

not specified

Species:

other: Human

Strain:

not specified

Sex:

not specified

Route of administration:

not specified

Vehicle:

not specified

Duration and frequency of treatment / exposure:

not specified

Remarks:

no specified

No. of animals per sex per dose / concentration:

not specified

Control animals:

not specified

Positive control reference chemical:

not specified

Details on study design:

not specified

Details on dosing and sampling:

not specified

Statistics:

not specified

Preliminary studies:

not specified

Type:

absorption

Results:

4-(2-aminoethyl) phenol can be absorbed from the gastro-intestinal tract

Type:

distribution

Results:

4-(2-aminoethyl) phenol can penetrate most organs, including the brain. It can be deaminated by monoamine oxidase types A and B in a variety of tissues, including the wall of the gastro-intestinal tract and the central nervous system

Type:

metabolism

Results:

4-(2-aminoethyl) phenol can be conjugated, and production of tyramine-0-sulfate as a urinary metabolite

Details on absorption:

4-(2-aminoethyl) phenol can be absorbed from the gastro-intestinal tract

Metabolites identified:

yes

Remarks:

tyramine-0-sulfate

Conclusions:

4-(2-aminoethyl)phenol is likely to exhibit low bio-accumulation potential based on study results and use.

Executive summary:

Available data pertaining to the in-vivoAbsorption, Distribution and Metabolism of the chemical 4-(2-aminoethyl)phenol suggests absorbed from the gastro-intestinal tract and distributed by penetrate in most organs, including the brain. It can be deaminated by monoamine oxidase types A and B in a variety of tissues, including the wall of the gastro-intestinal tract and the central nervous system.Metabolism of 4-(2-aminoethyl) phenolby conjugation, and production of tyramine-0-sulfate as a urinary metabolite.Thus, there is no evidence that they or their metabolites would accumulate in tissues and cause a concern for consumer safety. Also, the Use Therapeutically as the hydrochloride as a sympathomimetic agent. Hence it is concluded that 4-(2-aminoethyl)phenolis likely to exhibit low bio-accumulation potential based on study results and use.  

Description of key information

Tt is concluded that 4-(2-aminoethyl)phenolis likely to exhibit low bio-accumulation potential based on study results and use. 

Key value for chemical safety assessment

Bioaccumulation potential:

low bioaccumulation potential

Additional information

Available data pertaining to the in-vivoAbsorption, Distribution and Metabolism of the chemical 4-(2-aminoethyl)phenol suggests absorbed from the gastro-intestinal tract and distributed by penetrate in most organs, including the brain. It can be deaminated by monoamine oxidase types A and B in a variety of tissues, including the wall of the gastro-intestinal tract and the central nervous system. Metabolism of 4-(2-aminoethyl) phenolby conjugation, and production of tyramine-0-sulfate as a urinary metabolite.Thus, there is no evidence that they or their metabolites would accumulate in tissues and cause a concern for consumer safety. Also, the Use Therapeutically as the hydrochloride as a sympathomimetic agent. Hence it is concluded that 4-(2-aminoethyl)phenolis likely to exhibit low bio-accumulation potential based on study results and use.