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Diss Factsheets
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EC number: 203-514-5 | CAS number: 107-71-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-08-23 and 1978-12-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no 48-hour-observation; further time points necessary to evaluate fully reversibility
- GLP compliance:
- no
Test material
- Reference substance name:
- tert-butyl peracetate
- EC Number:
- 203-514-5
- EC Name:
- tert-butyl peracetate
- Cas Number:
- 107-71-1
- Molecular formula:
- C6H12O3
- IUPAC Name:
- tert-butyl ethaneperoxoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kuiper's Rabbit Ranch, Gary, Indiana
- Weight at study initiation: 2295 to 2933 grams
- Housing: individually housed in hanging wire-mesh cages
- Diet: Purina® Rabbit Chow®, ad libitum
- Water: ad libitum
- Acclimation period: 14 days
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped and abraded
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours
- Number of animals:
- 3 males
3 females - Details on study design:
- TEST SITE
- Area of exposure: back of each rabbit under a one inch square gauze patch
- % coverage: 20 -30% of the body surface
- Type of wrap: the application sites were covered with gauze bandaging and overwrapped with Saran Wrap. The entire application area was then wrapped with several layers of 75 mm Elastoplast tape. A collar was also applied.
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h/ 72 h
- Score:
- 0.75
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: individual scores for intact skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h/ 72 h
- Score:
- 0.25
- Max. score:
- 4
- Reversibility:
- fully reversible within:
- Remarks on result:
- other: individual scores for intact skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24 h/ 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: individual scores for intact skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 h/ 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: individual score for intact skin
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 h/ 72 h
- Score:
- 0.75
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: individual score for intact skin
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24 h/ 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: individual score for intact skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h/ 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: individual score for abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h/ 72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: individual score for abraded skin; blanching after 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24 h/ 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: individual score for abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 h/ 72 h
- Score:
- 0.75
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: individual score for abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 h/ 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: individual score for abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24 h/ 72 h
- Score:
- 0.75
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: individual score for abraded skin
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results obtained from the study show, that the mean values of the recordings 24 and 72 hours after treatment for both erythema and edema were in the range of 0 to 1 for all individual animals.
- Executive summary:
In a primary dermal irritation study (International Research and Development Corporation, 1978), three male and three female New Zealand White rabbits were dermally exposed to 0.5 mL of tert-butyl peracetate (75% (w/w) in mineral spirit) for 24 hours. The skin of three of the rabbits was abraded with a scalpel blade. Animals then were observed 24 and 72 hours after test item application. Irritation was scored by a modified method of Skin Reaction Code (National Academy of Sciences, 1977). The mean erythema score (24/72h) was 0.6 for intact skin and 0.5 for abraded skin and the mean edema score (24/72h) was 0.25 for intact and 0.5 for abraded skin. Based on the results tert-butyl peracetate (75 % (w/w) in mineral spirit) is not considered a dermal irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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