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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Principles of method if other than guideline:
Acute toxicity: intraperitoneal; neurotoxicity
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
hen
Strain:
other: Leghorn
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Doses:
2,5; 5 ml/kg bw.
No. of animals per sex per dose:
5/sex/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 000

Any other information on results incl. tables

 Dose (ml/lg  Neurotoxicological result
 2,5  0/4
 5  3/4*

* = 2 animals killed earlier because of strong paresis (week 5)

Applicant's summary and conclusion

Conclusions:
The LD 50 was >5000 ml/kg bw (i.p., hen).
Executive summary:

DPK was administered i.p. to hens. A clear neurotoxic effect was shown at a dose of 5 ml/kg bw.

The LD 50 was >5000 ml/kg bw.