Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP study defined
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Not applicable
- Molecular formula:
- C19 H17 O4 P1
- IUPAC Name:
- Not applicable
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 500 µl DPK
- Duration of treatment / exposure:
- 4h
- Observation period:
- 1, 24, 48, 72 h; 8d
- Number of animals:
- 3 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Erythema and edema score = 0 at 1h, 24, 48, 72 h and 8 days.
Any other information on results incl. tables
| Time after patch removal | Skin irritation/ Animal No: | |||
| 1 | 2 | 3 | ||
| Erythema | 1h | 0 | 0 | 0 |
| 24h | 0 | 0 | 0 | |
| 48h | 0 | 0 | 0 | |
| 72h | 0 | 0 | 0 | |
| 8d | 0 | 0 | 0 | |
| Edema | 1h | 0 | 0 | 0 |
| 24h | 0 | 0 | 0 | |
| 48h | 0 | 0 | 0 | |
| 72h | 0 | 0 | 0 | |
| 8d | 0 | 0 | 0 | |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Erythema and edema score = 0 at 1h, 24, 48, 72 h and 8 days.
- Executive summary:
In a study in Albino-rabbits according to OECD Guideline 404, DPK was tested as not irritating to the skin.
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