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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older study: meets scientific standards with acceptable restrictions (limited number of animals in study, partly limited documentation)
Qualifier:
no guideline available
Principles of method if other than guideline:
Study from 1959 (no guidelines available at the time the study was performed)
GLP compliance:
no
Remarks:
Study from 1959 (GLP was not compulsory at the time the study was performed)
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Wistar
Sex:
not specified
Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
Single dosing with 5 - 15 mL/kg (ca. 5 - 15 g)
No. of animals per sex per dose:
Dosed was a group of 5 animals (no further details reported)
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 21 d
Frequency of observations and weighing: not reported
Necropsy of survivors performed: not reported
Other examinations performed: body weight,organ weights, histopathology
Statistics:
Not further specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 7 000 mg/kg bw
Mortality:
Deaths occured at any dose level throughout the study.
Clinical signs:
other: The signs included weakness, depression, ataxia, hyperexcitability, unrest, urinary dribbling, irregular and labored respiration, and in the advanced phase of poisoning convulsions appeared in some of the animals.
Gross pathology:
Not reported
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
In this older study with Wistar rats the LD50 was estimated with ca. 7000 mg/kg.
Executive summary:

In this older study Wistar rats were dosed once with 5 - 15 mL/kg (ca. 5000 - 15000 mg/kg) via gavage. All animals were observed for signs of toxicity for 21 d following dosing. The dosing caused no deaths and the estimated LD50 was given with 7 mL/kg (ca. 7000 mg/kg).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
7 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Data from handbook
GLP compliance:
not specified
Species:
guinea pig
Strain:
not specified
Sex:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 mL/kg bw
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
> 10 000 mg/kg bw

Additional information

Dermal LD50 is >10 mL/kg bw

Justification for classification or non-classification

Based on the results of the available experiments, classification criteria are not met.