Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-066-5 | CAS number: 77-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- human patch test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from review article
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Acetyl Triethyl Citrate, Acetyl Tributyl Citrate, Acetyl Trihexyl Citrate, and Acetyl Trioctyl Citrate
- Author:
- Cosmetic Ingredient Review
- Year:
- 2 002
- Bibliographic source:
- International Journal of Toxicology, 21(Suppl. 2):1–17
- Reference Type:
- other: secondary citation
- Title:
- Repeated insult patch test on Citroflex 2 liquid, Citroflex A-2 liquid, and Citroflex A-4 liquid.
- Author:
- Hill Top Research, Inc.
- Year:
- 1 978
- Bibliographic source:
- Unpublished data submitted by CTFA, December 4, 1998. (3 pages.)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- ATEC was evaluated in 59 human subject panelists (males and females) in the repeated insult patch test of Draize. The test substance was found not to induce dermal irritation or contact sensitization. For this test, each of the 59 panelists received a test patch (20x20 cm) moistened with 0.4 mL of ATEC to the upper arms 3 times a week for 3 weeks. Patches were secured in place for 24 hours before removal. Duplicate challenges were made 2 weeks after the final serial applications, 1 set of patches to original sites and 1 set to adjacent sites. Patch sites were scored prior to patch applications and scored at 48 and 96 hours after applications.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- Existing study
Test material
- Reference substance name:
- Triethyl O-acetylcitrate
- EC Number:
- 201-066-5
- EC Name:
- Triethyl O-acetylcitrate
- Cas Number:
- 77-89-4
- Molecular formula:
- C14H22O8
- IUPAC Name:
- triethyl 2-acetoxypropane-1,2,3-tricarboxylate
Constituent 1
In vivo test system
Test animals
- Species:
- other: human
- Sex:
- male/female
- Details on test animals and environmental conditions:
- 59 human subject panelists (males and females)
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: Patch sites were scored prior to patch applications and scored at 48 and 96 hours after applications
- Dose level:
- 0.4 mL
- No. with + reactions:
- 0
- Total no. in group:
- 59
- Clinical observations:
- no data
- Remarks on result:
- other: Reading other:
- Remarks:
- Patch sites were scored prior to patch applications and scored at 48 and 96 hours after applications. Dose level: 0.4 mL. No with. + reactions: 0.0. Total no. in groups: 59.0. Clinical observations: no data.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- ATEC is not considered to have a sensitising potential.
- Executive summary:
ATEC was evaluated in 59 human subject panelists (males and females) in a repeated insult patch test of Draize. The test substance was found not to induce dermal irritation or contact sensitization.
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