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EC number: 273-114-3 | CAS number: 68938-07-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study report contains limited information, pre-GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Neodecanoic acid
- EC Number:
- 248-093-9
- EC Name:
- Neodecanoic acid
- Cas Number:
- 26896-20-8
- Molecular formula:
- C10H20O2
- IUPAC Name:
- neodecanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Versatic 10
- Substance type: liquid
- Analytical purity: assumed 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1, 1.5, 2, 3, or 4 ml/kg
- No. of animals per sex per dose:
- 4 per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days post dosing
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights - Statistics:
- LD50 value and 95% confidence intervals were calculated.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 066 mg/kg bw
- 95% CL:
- 1 693 - 2 530
- Remarks on result:
- other: Slope factor = 7.11
- Mortality:
- Animals that died did so within 3 days post exposure.
- Clinical signs:
- other: Lethargy, hypothermia, piloerection, dyspnea, ataxia
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
4 Animals per sex per dose group
| Daily Mortality | ||||||
| Dose ml/kg | 1 | 2 | 3 | |||
| M | F | M | F | M | F | |
| 1 | ||||||
| 1.5 | ||||||
| 2 | 3 | 1 | 1 | |||
| 3 | 2 | 1 | 1 | 1 | ||
| 4 | 1 | 4 | 3 | |||
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category V
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 is approximately 2.27 ml/kg (2066 mg/kg).
- Executive summary:
In this study, male and female rats were gavage with neodecanoic acid at concentrations of 1, 1.5, 2, 3, or 4 ml/kg. All animals that died during the study did so within 3 days of exposure. Signs of toxicity included lethargy, hypothermia, piloerection, dyspnea, and ataxia. Based on these results, it is concluded that the LD50 is approximately 2.27 ml/kg (2066 mg/kg).
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