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EC number: 244-289-3
CAS number: 21245-02-3
Correction factor for differences in respiratory volume (rat/workers): 1/0.38
Correction factor for light activity at work : 6.7/10
Correction factor for difference between human and experimental exposure conditions : 7/5 (In the study, animals were exposed 7 days per week, and workers work 5 days per week).
Oral absorption = 100 % (see section 7.1 Toxicokinetics)
Inhalation absorption = 100% (see section 7.1 Toxicokinetics)
NOAEC = NOAEL x (1/0.38) x (6.7/10) x 7/5= 100 x (1/0.38) x (6.7/10) x 7/5 = 247 mg/m3
Based on the TK assessment, a dermal absorption of 10% was used.
Dermal NOAEL = oral NOAEL x 100/10 x 7/5= 100 x 100/10 x 7/5 = 1400 mg/kg bw/day
Correction factor for differences in respiratory volume (rat/general population): 1/1.15
NOAEC = oral NOAEL x (1/1.15) = 100 x (1/1.15) = 87 mg/m3
Dermal NOAEL = oral NOAEL x 100/10 = 100 x 100/10 = 1000 mg/kg bw/day
No difference in oral absortion is expected between rats and humans.
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