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EC number: 230-237-7 | CAS number: 6976-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Product no. B4429, Lot no. SLBK5235V
- Expiration date of the lot/batch: 30 April 2018
- Purity test date: na
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0 and 120h
- Sampling method: -
- Sampling methods for the volatile compounds, if any: not applicable
- Sampling intervals/times for pH measurements: 0 and 120h
- Sampling intervals/times for sterility check: not applicable
- Sample storage conditions before analysis: not applicable (no storage)
- Other observation, if any (e.g.: precipitation, color change etc.): none - Buffers:
- - pH: 4, 7, 9
- Type and final molarity of buffer:
- Composition of buffer:
pH 4.0: 76.5 mL 0.1 M sodium acetate and 423.5 mL 0.1 M acetic acid;
pH 7.0: 250 mL 0.1 TRIS buffer and 233 mL 0.1 M hydrochlorid acid diluted to 500 mL with ultra-pure water;
pH 9.0: 53.5 mL 0.2 M sodium hydroxide and 125 mL 0.1 M boric acid and potassium chloride diluted to 500 mL with ultra-pure water) - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 20 mL headspace vials
- Sterilisation method: sterile working conditions
- Lighting: no information available
- Measures taken to avoid photolytic effects: no information available
- Measures to exclude oxygen: test tubes were filled up with test solutions
- Details on test procedure for unstable compounds: not applicable
- Details of traps for volatile, if any: not applicable
- If no traps were used, is the test system closed/open: no information available
- Is there any indication of the test material adsorbing to the walls of the test apparatus? none
TEST MEDIUM
- Volume used/treatment: 20 mL
- Kind and purity of water: ultra-pure sterile water
- Preparation of test medium: 250 mg dissolved in each buffer solution to a total volume of 250 mL
- Renewal of test solution: none
- Identity and concentration of co-solvent: not applicable - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.99 µg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.99 µg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.95 µg/L
- Number of replicates:
- 5 per pH
- Positive controls:
- no
- Negative controls:
- yes
- Preliminary study:
- Recovery after 120h at 50°C:
- pH 4: 105%
- pH 7: 95%
- pH 9: 96%
Therefore, it was concluded that the substance is hydrolytically stable and no further experiments were conducted. - Transformation products:
- not measured
- % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 95
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 96
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
- Anomalies or problems encountered (if yes):
MAJOR TRANSFORMATION PRODUCTS: - not applicable
MINERALISATION (distinguish between dark and irradiated samples): not applicable
INDICATION OF UNSTABLE TRANSFORMATION PRODUCTS: none
VOLATILIZATION (at end of study): none
UNIDENTIFIED RADIOACTIVITY (at end of study): not applicable
PATHWAYS OF HYDROLYSIS: not applicable - Validity criteria fulfilled:
- yes
- Executive summary:
The hydrolysis of the substance as a function of pH was determined in a preliminary test according to OECD Test Guideline 111 under GLP conditions.
As no hydrolysis was observed at pH 4, 7 and 9 at 50°C for 120h, it was concluded that the substance is hydrolytically stable and the hydrolysis was not investigated further.
Reference
The hydrolysis of the substance as a function of pH was determined in a preliminary test according to OECD Test Guideline 111 under GLP conditions.
As no hydrolysis was observed at pH 4, 7 and 9 at 50°C for 120h, it was concluded that the substance is hydrolytically stable and the hydrolysis was not investigated further.
Description of key information
In a preliminary test, the substance was hydrolytically stable.
Key value for chemical safety assessment
Additional information
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