Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-995-3 | CAS number: 1071-76-7
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 56.6 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECETOC technical report no. 86
- Overall assessment factor (AF):
- 6
- Dose descriptor starting point:
- NOAEC
- Value:
- 676 mg/m³
- Explanation for the modification of the dose descriptor starting point:
NOAEC from rat subchronic inhlation study = 676 mg/m3 (David, 2001, UNEP 2004)
Modification of the dose descriptor according to ECHA Guidance R.8
Corrected inhalatory NOAEC = inhalatory NOAEC * (exp.time rat/exp.time worker) * (ABS rat/ABS human) * (sRVhuman 8h/wRV)
ABS – absorption (assumed 100% in human and in experimental animamals)
sRVhuman – respiratory volume under standard conditions
wRV – respiratory volume light activity for worker
Corrected NOAEC = 676 mg/m3 * ( 6 h/d / 8 h/d) * (100/100) * (6.7 m3/ 10 m3) = 339.7 mg/m3
Assessment factors – based on ECETOC (2003) technical report no. 86
Intraspecies difference for worker = 3
exposure duration subchronic to chronic = 2
Overall AF = 3*2 = 6
DNEL worker systemic effects by inhalation = 339.7 / 6 = 56.6 mg/m3
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The substance is classified for eye damage category 1 and skin irritation category 2 and STOT SE 3 (drowsiness); moderate hazard is assigned according to ECHA CSA guidance Part E Table E 3-1. Risk characterisation is conducted qualitatively.
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
- Most sensitive endpoint:
- acute toxicity
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
None.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
None.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
