Zirconium tetrabutanolate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Justification for type of information:

1-butanol is the main hydrolysis prodcuts of the target substance. Properties of the the hydrolysis substance are used for read-across.

Data source

Reference

Reference Type:

publication

Title:

Food Flavourings and Compounds of Related Structure; I. Acute Oral Toxicity

Author:

Jenner PM, Hagan EC, Taylor JM, Cook EL and Fitzhugh OG

Year:

1964

Bibliographic source:

Fd. Cosmet. Toxicol. 2: 327-343

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: other

Principles of method if other than guideline:

Groups of 10 young adult Osborne-Mendel rats evenly divided by sex were fasted for approximately 18 hours prior to treatment with different doses of the test substance. Doses are not reported, no data on preparation of dosing solutions, no data on body weight gains etc., no data on necropsies.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Butan-1-ol

EC Number:

200-751-6

EC Name:

Butan-1-ol

Cas Number:

71-36-3

Molecular formula:

C4H10O

IUPAC Name:

butan-1-ol

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 2 510 mg/kg bw

Based on:

test mat.

95% CL:

>= 2 220 - <= 2 840

Mortality:

Mortality occured 4-18 hours after dosing, no further data

Clinical signs:

other: depression, coma

Gross pathology:

not reported

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The oral LD50 on rats was 2510 mg/kg bw. Meet acute oral toxicity category 5 according to GHS.

Executive summary:

As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.