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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Effect of acute combined exposure to N-butyl alcohol and m-xylene
Author:
Korsak S., Swiecz, R., and Jedrychowski R.
Year:
1993
Bibliographic source:
Polish Jor. of Occup. Med. and Environmental Health. 6(1): 35-41

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: other
Principles of method if other than guideline:
disturbance of rotarod performance
GLP compliance:
not specified
Test type:
other: reduction in respiratory rate

Test material

Constituent 1
Reference substance name:
Butan-1-ol
EC Number:
200-751-6
EC Name:
Butan-1-ol
Cas Number:
71-36-3
Molecular formula:
C4H10O
IUPAC Name:
butan-1-ol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
air
Duration of exposure:
ca. 4 h
No. of animals per sex per dose:
10 male rats per group
Control animals:
yes

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 6 531 ppm
Based on:
other: rotarod performance
Exp. duration:
4 h

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
pratically non toxic.