Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-405-2 | CAS number: 106-51-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- comparison of GMPT and LLNA (publication)
Test material
- Reference substance name:
- p-benzoquinone
- EC Number:
- 203-405-2
- EC Name:
- p-benzoquinone
- Cas Number:
- 106-51-4
- Molecular formula:
- C6H4O2
- IUPAC Name:
- 1,4-benzoquinone
1
- Specific details on test material used for the study:
- source: Sigma
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Albino Dunkin-Hartley guinea-pigs weighed approximately 350 g at the start of the study.
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal
- Vehicle:
- other: acetone-polyethylene glycol 400 (70:30, v/v)
- Concentration / amount:
- 0.005 %
- Day(s)/duration:
- 6-8
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: acetone-polyethylene glycol 400 (70:30, v/v)
- Concentration / amount:
- 2.5 %
- Day(s)/duration:
- 1
- Adequacy of challenge:
- highest non-irritant concentration
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0,005% II, 10% IP, 2,5% CP
- Clinical observations:
- extreme sensitizing
- Remarks on result:
- other: 100% response
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0,005% II, 10% IP, 2,5% CP
- Clinical observations:
- extreme sensitizing
- Remarks on result:
- other: 100% response
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- p-Benzoquinone is an extreme sensitizer in the GPMT.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
