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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE
EPI-SUITE EPA (USA)

2. MODEL (incl. version number)
ECOSAR v1.11

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
SMILES: c1cc(c(cc1C(F)(F)F)O)C(=O)O

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The QMRF is available in "Attached justification".

5. APPLICABILITY DOMAIN
The QPRF is available in "Attached justification".

6. ADEQUACY OF THE RESULT
The QPRF is available in "Attached justification".
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.1, EPA, USA (QSAR Prediction Reporting Format (QPRF) attached).
GLP compliance:
no
Specific details on test material used for the study:
SMILES: c1cc(c(cc1C(F)(F)F)O)C(=O)O
Test organisms (species):
Daphnia magna
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
22.296 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: ECOSAR predicted value
Details on results:
ECOSAR Class: Phenols-acid

ECOSAR v1.11 Class-specific Estimation (Phenols-acid ) predicted that the test item has an LD50 (48h) of 22.296 mg/L for Daphnid.

Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 48 -h LC50 for Daphnia is 22.296 mg/l (ECOSAR v1.11, Phenols-acid).
Executive summary:

The estimated 48 -h LC50 for Daphnia is 22.296 mg/l (ECOSAR v1.11, Phenols-acid).

Description of key information

Key study: Internationally accepted method, ECOSAR, EPA (USA). The estimated 48h LC50 for Daphnia is 22.296 mg/l (ECOSAR v1.11, phenols-acid).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
22.296 mg/L

Additional information

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