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Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
The growth of Colpidium campylum has been determined in a 43 h test and the minimal active dose was determined.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
yes
Remarks:
Final concentration 0.25 mL acetone/ 50 mL test solution
Test organisms (species):
Colpidium campylum
Test type:
static
Water media type:
not specified
Total exposure duration:
43 h
Test temperature:
20°C
Details on test conditions:
TEST SYSTEM
- Fill volume: 50 mL
- No. of vessels per concentration (replicates): 5
- No. of vessels per vehicle control (replicates): 5

Further information is depicted in the illustration below.
Duration:
43 h
Dose descriptor:
LOEC
Effect conc.:
> 10 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Details on results:
At the highest concentration tested (10 mg/L), no inhibition of the growth of Colpidium campylum was observed when compared to the solvent control.
Reported statistics and error estimates:
covariance analysis
Conclusions:
43 h- LOEC Colpidium campylum: > 10 mg/L (highest tested concentration)
Executive summary:

At the highest concentration tested (10 mg fenuron /L), no inhibition of the growth of Colpidium campylum was observed when compared to the solvent control.

Even if Colpidium campylum is not a standard test organisms, the result is considered to be relevant for the risk assessment of fenuron since the test was performed as reproduction test.

According to Granner and Foissner (1989) this species was also found in sewage treatment plants and is hence relevant.

Bruno Ganner und Wilhelm Foissner:Taxonomy and ecology of some ciliates (Protozoa, Ciliophora) of the saprobic system. III. Revision of the genera Colpidium and Dexiostoma, and establishment of a new genus, Paracolpidium nov. gen.Hydrobiologia, Volume 182, Number 3, S. 181–218, Verlag Springer Netherlands, September 1989

Description of key information

43 h- LOEC Colpidium campylum: > 10 mg/L (highest tested concentration)

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
10 mg/L

Additional information

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