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Registration Dossier
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EC number: 202-941-4 | CAS number: 101-42-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1978
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Principles of method if other than guideline:
- The tests were performed according to the original protocol with some minor technical modifications.
- GLP compliance:
- not specified
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- Fenuron
- EC Number:
- 202-941-4
- EC Name:
- Fenuron
- Cas Number:
- 101-42-8
- Molecular formula:
- C9H12N2O
- IUPAC Name:
- fenuron
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- Fenuron was synthesized in our laboratory by the reaction of methyl- or dimethyl-amine with an appropriately substituted phenyhsocyanate. These mostly very vigorous reactions were carried out in ethereal solutions at 5°C, yielding pure crystalline ureas after standing overnight at room temperature.
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Doses / concentrations
- Dose / conc.:
- 1 000 mg/kg bw/day
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Examinations
- Tissues and cell types examined:
- bone marrow
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Table1. Percentage of Micronucleated polychromatic erythrocytes in bone marrow of mice treated with FenuronO MICE TREATED
Dose (mg/kg) per os |
Number of animals |
Micronucleated erythrocytes (%) |
1000 |
6 |
0.17 |
Applicant's summary and conclusion
- Conclusions:
- Fenuron tested negative in the in vivo micronucleus test in mice after oral dosing at 1000 mg/kg bw/day.
- Executive summary:
The in vivo micronucleus test was performed according to the original protocol with some minor technical modifications.
6 mice received 1000 mg/kg bw/day Fenuron per os. As a result, 0.17% micronucleated polychromatic erythrocytes were observed in bone marrow cells of the treated mice.
Fenuron was negative under the test conditions used.
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