Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not specified
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Final Report on the Safety Assessment of Sodium Iodate
Author:
Cosmetic Ingredient Review (Expert Panel)
Year:
1995
Bibliographic source:
Journal of the American College of Toxicology 14(3):231-239, Raven Press, Ltd., New York

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
An Ames test was conducted with the substance
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium iodate
EC Number:
231-672-5
EC Name:
Sodium iodate
Cas Number:
7681-55-2
Molecular formula:
HIO3.Na
IUPAC Name:
sodium iodate

Results and discussion

Test results
Key result
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
The test material showed no mutagenic activity by the Ames test.
Executive summary:

The test material showed no mutagenic activity by the Ames test.