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EC number: 236-501-8
CAS number: 13410-01-0
For acute oral toxicity a reliable study on rats dosed with sodium
selenite by gavage is available, which stated a LD50 of 7 mg sodium
selenite /kg. Acute toxicity after inhalation is derived from a reliable
study on rats using disodium selenate as testing substance with a LC50
(4 h) of above 0.052 up to 0.51 mg sodium selenate /L.
All Selenium compounds (organic and inorganic), do share the very same
metabolic fate in that after their resorption reduction to the selenide
moiety [Se2-] takes place which is the single common precursor for its
further metabolic conversion (Ohta and Suzuki (2008)). From this
follows, that data for disodium selenite fits also for the toxicological
assessment of sodium selenate.
Moreover, the water solubility, as prerequisite of the bioavailability
of such inorganic substances, is comparable for sodium selenate and
water solubility of sodium selenite: 800 -900 g/L
water solubility of disodium selenate: 585 g/L
No data are available for the dermal route, hower dermal is not
considered to be the major route of exposure for sodium selenate.
Furthermore, the physicochemical and toxicological properties do not
suggest potential for significant rate of absorption through the skin.
No data gaps were identified. The available data are adequate for risk
assessment and classification and labelling purposes.
Justification for selection of acute toxicity – oral endpoint
The key study is of good quality (Klimisch 2).
Justification for selection of acute toxicity – inhalation endpoint
The key study is of high quality (Klimisch 1)
Selenium compounds are subject to legal binding
classification. Based on harmonised classification, CLP Regulation (EC)
No 1272/2008, Annex VI, table 3.1 Selenium has to be classified and
labelled as follows:
Acute Tox. 3* -
H301: Toxic if swallowed.
Acute Tox. 3* - H331:
Toxic if inhaled
This classification is a minimum classification which
needs to be reevaluated on basis of acutal data set.
According to the CLP Regulation (EU GHS Regulation (EC)
No 1272/2008) the following classification and labelling is required for
sodium selenate, based on acute oral toxicity value of LD50 = 7 mg/kg bw
and an acute inhaltion toxicity value of LC50 > 0.052 and ≤ 0.51 mg/L
Acute Tox. 2 H300: Fatal if swallowed.
Acute Tox. 2 H330: Fatal if inhaled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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