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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets



Category name:
Vanadium (III) acetylacetonate and hydrolysis products

Justifications and discussions

Category definition:
Vanadium (III) acetylacetonate and hydrolysis products
Category rationale:
There is data available on the hydrolysis behaviour of the registered substance Vanadium (III) acetylacetonate in a buffered methanol solution at different pH (1.2, 4, 7, 9) at room temperature. The hydrolytic degradation of Vanadium (III) acetylacetonate can be described as a pseudo-first order kinetic and the half-life of vanadium (III) acetylacetone was determined to be < 0.5 h. Vanadyl (2+) ion (CAS 20644-97-7) and acetylacetonate (CAS 123-54-6) were identified as degradation products. It can be concluded that the substance hydrolyzes extremely rapid in contact with water. Hence, it is not meaningful to test or present literature data of the substance as such. It is sufficient for hazard assessment to use data gained with Vanadyl (2+) ion (CAS 20644-97-7) and acetylacetonate (CAS 123-54-6) . As there are only few data existing for Vanadyl (2+) ion, data from vanadium compounds with a higher valence were used for read-across purpose as well, justified by the fact that the toxicity of Vanadium generally increases as valency increases (see IPCS, EHC 81 "Vanadium", 1988, page 35 and IARC Monographs Volume 86 "Vanadium pentoxide", page 258). In addition several peer-reviewed publications for Vanadium and other inorganic compounds also state that oral studies in rats and mice demonstrate greater toxicity of vanadium as oxidation state increases (e.g. see CICAD 29 "Vanadium pentoxide and other inorganic vanadium compounds", WHO 2001, page 15; NTP TR 507 "Vanadium pentoxide", 2002, page 19 and MAK, 41. Lieferung, 2006, page 13).