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EC number: 236-759-1 | CAS number: 13476-99-8
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-05-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- sieving
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- Mass median aerodynamic diameter:
- >= 50 - <= 160 µm
- Geometric standard deviation:
- 0
- Key result
- Percentile:
- other: D98
- Mean:
- 160 µm
- Remarks on result:
- other: no St. dev. stated in the report
- No.:
- #1
- Size:
- 50 µm
- Distribution:
- 0 %
- No.:
- #2
- Size:
- 75 µm
- Distribution:
- 0.43 %
- No.:
- #3
- Size:
- 100 µm
- Distribution:
- 0.57 %
- No.:
- #4
- Size:
- 125 µm
- Distribution:
- 1 %
- No.:
- #5
- Size:
- 160 µm
- Distribution:
- 98.01 %
- Conclusions:
- The volume median diameter was determined to be > 160 µm. More than 98% of the particles in the sample have a particle size > 160 µm, whereas the remaining 2% show the following distribution:
- 1.0% of test material having a diameter o 125 - 160 µm
- 0.57% of the test material having a diameter of 100 - 125 µm
- 0.43% of the test material having a diameter of 75 - 100 µm
- 0.00 % of the test material having a diameter of 50 - 75 µm - Executive summary:
Using the laser diffraction (ISO 13320) method to study the particle size of DL-Alanine, the volume median diameter (Dv50) was determined to be 144.1 µm (arithmetic mean of four measurements). The particle size distribution was found to range from approximately 1 µm to 500 µm.
68% of the particles in the sample have a particle size > 100 µm, whereas the remaining 32% show the following distribution:
- 2.6% of test material having a diameter < 5 µm
- 0.8% of the test material having a diameter of 5 - 10 µm
- 28.6% of the test material having a diameter of 10 - 100 µm.
Reference
Description of key information
Using the laser diffraction (ISO 13320) method to study the particle size of DL-Alanine, the volume median diameter (Dv50) was determined to be 144.1 µm (arithmetic mean of four measurements). The particle size distribution was found to range from approximately 1 µm to 500 µm.
68% of the particles in the sample have a particle size > 100 µm, whereas the remaining 32% show the following distribution:
- 2.6% of test material having a diameter < 5 µm
- 0.8% of the test material having a diameter of 5 - 10 µm
- 28.6% of the test material having a diameter of 10 - 100 µm.
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