Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics, other
Type of information:
other: evaluation of available information
Adequacy of study:
key study

Data source

Materials and methods

Test material

Constituent 1
Test material form:
solid: particulate/powder

Results and discussion

Applicant's summary and conclusion

Executive summary:

No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS405966. Its systemic availability after topical or oral administration is expected to be limited, because of its relatively high molecular weight (approx. 600 Da), low water solubility (< 1 mg/l) and high lipohilicity (log Pow > 6). Availability of WS405966 under a vapour state is unlikely, because of its low vapour pressure (3 x 10-5 Pa).

Based on the available data the bioacumulation potential cannot be judged. However, based on the favourable testing results, i.e. absence of adverse effects in any of the studies performed according to the REACH Regulation annexes VII and VIII, on the one hand and on the very low dermal and inhalative bioavailability of the substance (due to its physical-chemical properties) on the other hand there is no need for further investigations of a bioaccumulation potential.