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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
Read across justification
Qualifier:
according to guideline
Guideline:
other: German Industrial Standard DIN 38412 part 9
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
pH:
tested in neutralised and non-neutralised test medium in parallel
Details on test conditions:
- algae test apparatus with quasi-continuous determination of optical density
- counting of cell numbers
- photometric determination of turbidity at pre-determined times
- test solutions tested non-neutralized and neutralize
Reference substance (positive control):
no
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
512 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: neutralised
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
26 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: neutralised
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
216 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: non-neutralised
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
7.9 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: non-neutralised
Validity criteria fulfilled:
yes
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
RA
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: not specified
Deviations:
not specified
Principles of method if other than guideline:
not specified
GLP compliance:
not specified
Test organisms (species):
Skeletonema costatum
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
410 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
72 h ErC50 = 410 mg/L (growth rate method; nominal)

Description of key information

Testing was considered not necessary as alternatives to testing were available and they demonstrated to be sufficient to fulfil the legal requirements related to Annex VII, Section 9.1.1 of REACH. Therefore, the general rules for adaptation 1.2 of Annex XI of REACH regulation are met and applied. The results obtained from the three publications available from were in the EC50 range 410 -216 mg/l. the EC50 of 216 mg/l has been chosen as key for the CSA.

Key value for chemical safety assessment

EC50 for freshwater algae:
216 mg/L

Additional information