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EC number: 203-744-6 | CAS number: 110-18-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11/08/2017 - 31/01/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch Nº: 17F-1069978
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -0.13
- Temp.:
- 20.2 °C
- pH:
- ca. 10.2
- Details on results:
- The determined value of the logarithm of the partition coefficient was within the acceptable range of ± 0.3 log units
- Conclusions:
- The determined partition coefficient (log Pow) at 20.2 ºC is -0.13. The determined value of the logarithm of the partition coefficient was within the acceptable range of ± 0.3 log units.
- Executive summary:
The n-octanol/water partition coefficient of the test item was determined according to OECD guideline 107 and EC method A.8 (440/2008/EEC). The analytical method was validated following SANCO/3029/99, rev. 4. The determined partition coefficient (log Pow) at 20.2 ºC was -0.13.
Reference
Water: octanol ratio (water volume: octanol volume) |
Determination |
Conc. Of analyte in water phase (mg/L) |
Conc. Of analyte in organic phase (mg/L) |
Log Pow |
Mean log Pow |
Overall mean (± SD) |
pH of water phase |
1:1 (40 mL : 40 mL) |
1 |
57.68 |
43.44 |
-0.12 |
-0.12 |
-0.13 (± 0.01) |
10.18 |
2 |
57.45 |
43.56 |
-0.12 |
10.21 |
|||
2:1 (50 mL : 25 mL) |
1 |
39.43 |
38.42 |
-0.14 |
-0.14 |
10.17 |
|
2 |
39.66 |
28.82 |
-0.14 |
10.15 |
|||
1:2 (25 mL : 25 mL) |
1 |
83.27 |
61.67 |
-0.13 |
-0.13 |
10.26 |
|
2 |
83/72 |
61.80 |
-0.13 |
10.21 |
Description of key information
The n-octanol/water partition coefficient of the test item was determined according to OECD guideline 107 and EC method A.8 (440/2008/EEC). The analytical method was validated following SANCO/3029/99, rev. 4. The determined partition coefficient (log Pow) at 20.2 ºC was -0.13.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.13
- at the temperature of:
- 20.2 °C
Additional information
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