Registration Dossier
Registration Dossier
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EC number: 203-744-6 | CAS number: 110-18-9
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.021 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.021 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.002 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 5.67 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.092 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.009 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.006 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
Experimental data investigating the ecotoxicity of TMEDA are available from a short-term fish toxicity study, a short-term Daphnia toxicity study and an algal growth inhibition study. Long-term ecotoxicity data are not available for fish or aquatic invertebrates. The algal growth inhibition study showed the most conservative toxicity data from these studies, having resulted in a 72-h ErC50 value of 20.5 mg/L and a 72-h NOEC of 0.954 mg/L.
A ready biodegradability study according to the OECD guideline 301B is available, the results of which concluded that TMEDA is not readily biodegradable.
Based on the above information, self-classification would assume that TMEDA is not classified for acute aquatic toxicity under the CLP regulation (Regulation (EC) No 1272/2008) but is classified as acute aquatic toxicity, Category 2 (H401) under the Globally Harmonised System (GHS), and is also classified as chronic aquatic toxicity, Category 2 (H411) under both the CLP regulation and GHS. However, a harmonised classification (Annex VI) is available for TMEDA which concludes that the substance is not classified for either acute or chronic aquatic toxicity.
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