Registration Dossier
Registration Dossier
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EC number: 204-370-6 | CAS number: 120-11-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Benzyl 2-methoxy-4-prop-1-enylphenyl ether
- EC Number:
- 204-370-6
- EC Name:
- Benzyl 2-methoxy-4-prop-1-enylphenyl ether
- Cas Number:
- 120-11-6
- Molecular formula:
- C17H18O2
- IUPAC Name:
- benzyl 2-methoxy-4-prop-1-enylphenyl ether
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: unspecified
- No. of animals per sex per dose:
- 3
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item BENZYL ISO EUGENOL does not have to be classified in accordance with the Regulation EC no. 1272/2008 on classification, labelling and packaging of substances and mixtures. No signal word or hazard statement is required.
- Executive summary:
The test item BENZYL ISO EUGENOL was administered to a group of 6 female Sprague Dawley rats at the dose of 2000 mg/kg bw. The experimental protocol was established according to the official method as defined in the OECD Test Guideline No. 423 dated December 17th, 2001 and the test method B.1tris of the Council regulation No. 440/2008 of 30 May 2008.
No mortality occured during the study.
No clinicals signs related to the administration of the test item were observed during the study.
The body weight evolution of the animals remained normal during the study.
The macroscopic examination of the animals at the end of the study did not reveal treatment related changes.
In conclusion, the LD50 of the test item BENZYL ISO EUGENOL is higher than 2000 mg/kg bw.
In accordance with the OECD Test Guideline No. 423, the LD50 cut-off of the test item may be considered as 5000 mg/kg bw by oral route in the rat.
The test item BENZYL ISO EUGENOL does not have to be classified in accordance with the Regulation EC No. 1272/2008 on classification, labelling and packaging of substances and mixtures.
No signal word or hazard statement is required.
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