Registration Dossier
Registration Dossier
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EC number: 203-601-8 | CAS number: 108-63-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects within the limits of water solubility; read-across
Key value for chemical safety assessment
Additional information
There is no study available, in which the short-term toxicity of Bis(1-methylheptyl) adipate (CAS 108-63-4) to fish was assessed. Therefore, read-across to the structurally and chemically closely related source substances Bis(7-methyloctyl) adipate (CAS 33703-08-1), Dioctyl adipate(CAS 123-79-5) and Bis(2-ethylhexyl) adipate (CAS 103-23-1) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, section 1.5 in order to fulfil the data requirements for this substance. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in detail within the analogue justification in IUCLID Section 13.
The acute toxicity of the source substance Bis(7-methyloctyl) adipate (CAS 33703-08-1) to fish was assessed in a study performed according to German standard test guideline, DIN 38 412 L15. The tested concentrations were 10, 100, and 500 mg/L. The required amount of substance was added to the test medium without any pre-treatment. Mortality or symptoms of intoxication of the fish (Leuciscus idus) were not observed at any of the tested concentrations. Thus the reported LC50 (96 h) was > 500 mg/L (nominal).
The acute toxicity of the source substance Dioctyl adipate (CAS 123-79-5) was tested in a study following ISO-guideline 7344/2 (similar to OECD 203). The semi-static test was conducted with zebra fish (Danio rerio) at nominal test substance concentrations of 100, 3000 and 10000 mg/L. The test substance was directly weighted into the test vessels and the test solutions were renewed daily. The determined LC50 (96 h) was 5500 mg/L (nominal).
The available study on the source Bis(2-ethylhexyl) adipate (CAS 103-23-1) was conducted in line with OECD Guideline 203. Fish of the species Oryzias latipes were exposed to a nominal concentration of 50 mg/L in a semi-static test system. The measured test substance concentration was 45 mg/L (geometric mean). The determined LC50(96 h) was >45 mg/L (meas. geom. mean.).
Based on the available data for the read across substances no acute toxic effects on fish are expected within the limits of water solubility of the target substance Bis(1-methylheptyl) adipate (CAS 108-63-4).
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