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EC number: 946-248-1 | CAS number: -
- Life Cycle description
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- Appearance / physical state / colour
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- After some preliminary observations, the test material was given undiluted, by gavage to groups of five males and five females, in one single dose of 10.0 ml per kg body weight.
After treatment the rats received stock diet and tap water as libitum.
They were observed for signs of intication during 14 day period, after which autopsies were carried out on the survivors. - GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Citronellyl 3-methylcrotonate
- EC Number:
- 244-019-4
- EC Name:
- Citronellyl 3-methylcrotonate
- Cas Number:
- 20770-40-5
- Molecular formula:
- C15H26O2
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yl 3-methylbut-2-enoate
- Reference substance name:
- 3,7-dimethyloctyl 3-methyl-2-butenoate
- EC Number:
- 275-360-7
- EC Name:
- 3,7-dimethyloctyl 3-methyl-2-butenoate
- Cas Number:
- 71383-07-8
- Molecular formula:
- C15H28O2
- IUPAC Name:
- 3,7-dimethyloctyl 3-methylbut-2-enoate
- Reference substance name:
- 3,7-dimethyloct-7-en-1-yl 3-methylbut-2-enoate
- Cas Number:
- 74499-48-2
- Molecular formula:
- C15H26O2
- IUPAC Name:
- 3,7-dimethyloct-7-en-1-yl 3-methylbut-2-enoate
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- A 50 ml sample of the test material was received from the principal in January 1978. It was a colourless liquid with a pugent odour, designated Sinodor 688 and coded M-76-193.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Young adult albino rats (wistar-derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats (Wistar-derived) from the Institue's colony were used. The body weights of males varied from 209 to 248g, those of females from 145 to 186g. The rats were housed in groups of five in screen-bottomed stainless steel cages, in a well-ventilated room, maintained at 23-25°C. Before dosing the rats were fasted overnight.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- After some preliminary observations, the test material was given undiluted, by gavage to groups of five males and five females, in one single dose of 10.0 ml per kg body weight.
- Doses:
- 10.0 ml per kg body weight
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- After some preliminary observations, the test material was given undiluted, by gavage to groups of five males and five females, in one single dose of 10.0 ml per kg body weight. Due to the small quantity of the test material, no higher doses could be given. After treatment the rats received stock diet and tap water ad libitum. They were observed for signs of intoxication during a 14 day period, after which autopsies were carried out on the survivors.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths
- Mortality:
- No deaths occured
- Clinical signs:
- other: Within a few hours after dosing the rats showed signs of sluggishness and decreased activity. Later on the rats recovered and looked quite healthy during the remaining part of the observation period. Macroscopic examination of the survivors at autopsy r
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From these results it appears that the oral LD50 of Sinodor exceeds 10 ml per kg body weight.
- Executive summary:
Acute oral toxicity was determined with a method similar to OECD Guideline 401.
At a dose of 10 ml/kg body weight, no deaths occured and clinical signs a few hours after dosing were that the rats showed signs of sluggishness and decreased activity.
Later on the rats recovered and looked quite healthy during the remaining part of the observation period. Macroscopic examination of the survivors at autopsy revealed no treatment related gross alterations.
From these results it appears that the oral LD50 of Sinodor exceeds 10 ml per kg body weight, GHS criteria not met.
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