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Administrative data

Endpoint:
thermal stability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 January - 21 February 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
EC Number:
222-468-7
EC Name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
Cas Number:
3483-12-3
Molecular formula:
C4H10O2S2
IUPAC Name:
1,4-disulfanylbutane-2,3-diol
Specific details on test material used for the study:
Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen

Results and discussion

For thermal stability study

Test substance thermally stable:
yes
Operating temperatureopen allclose all
Key result
Operating temp.:
ca. 30 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
ca. 290 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
ca. 300 °C
Remarks on result:
other: exothermic effect
Sublimation:
not determined
Transformation products:
not specified

Any other information on results incl. tables

The test item in closed glass crucibles showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290 °C, which was directly followed by an exothermic effect starting at a temperature of 300 °Cwith an average energy release of -50 J/g.

Results of the DSC-measurement

No.   Sample weight/mg Onset/°C   Range of Effect/°C
 PN19027  4.23

 30

290

300

+120 (endothermic)
+30 (
endothermic) 

-60 (exothermic)

 PN19050  7.50

 30

290

300

 +100 (endothermic)
+30 (
endothermic) 

-40 (exothermic)

Applicant's summary and conclusion

Conclusions:
The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290°C, which was directly followed by an exothermic effect starting at a temperature of 300°C with an average energy release of -50 J/g.
Executive summary:

The test item1,4-Dithiothreitol (CAS no. 3483-12-3) showed an endothermic effect starting at a temperature of approx. 30°C, which can be assigned to the melting of the test item. A second endothermic effect was observed starting at a temperature of 290°C, which was directly followed by an exothermic effect starting at a temperature of 300°C with an average energy release of -50 J/g.

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