ethyl 5,5-diphenyl-2-isoxazoline-3-carboxylate

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Principles of method if other than guideline:

The solubility of technical grade of the test item has been determined in a range of organic solvents at 20°C

GLP compliance:

yes

Medium:

other: n-heptane

Solubility:

3.7 g/L

Temp.:

20 °C

Remarks on result:

other: g/L solution

Medium:

other: p-xylene

Solubility:

>= 120 - <= 150 g/L

Temp.:

20 °C

Remarks on result:

other: g/L solvent

Medium:

other: 1,2-dichloroethane

Solubility:

>= 300 - <= 600 g/L

Temp.:

20 °C

Remarks on result:

other: g/L solvent

Medium:

methanol

Solubility:

>= 25 - <= 30 g/L

Temp.:

20 °C

Remarks on result:

other: g/L solvent

Medium:

acetone

Solubility:

>= 200 - <= 300 g/L

Temp.:

20 °C

Remarks on result:

other: g/L solvent

Medium:

ethyl acetate

Solubility:

>= 200 - <= 300 g/L

Temp.:

20 °C

Remarks on result:

other: g/L solvent

Preliminary Test

 

Solvent	Mass of HOE 1 22006/g	Total volume of solvent added				Solubility g/L solvent
		1 mL	2 mL	5 mL	10 mL
n-heptane	0.1086	x	x	x	x
	0.0104	x	x	dissol		2 to5
p-xylene	0.1044	dissol				> 100
1,2-dichloroethane	0.1007	dissol				> 100
methanol	0.1004	x	x	dissol		20 to 50
acetone	0.1046	dissol				> 100
ethyl acetate	0.1033	dissol				> 100

x = undissolved material remaining

dissol = sample totally dissolved

Solubility- Direct Addition Method

 

Solvent	Mass of HOE 1 22006/g	Total volume of solvent added mL							Solubility g/L solvent
		1mL	2mL	3mL	4mL	5mL	6mL	7mL	120 to 150
p-xylene	0.6010	x	x	x	x	dissol			120 to 150
	0.6010	x	x	x	x	dissol			300 to 600
1,2-dichloroethane	0.6002	x	dissol						300 to 600
	0.5991	x	dissol						25 to 30
methanol	0.1498			x	x	x	dissol		25 to 30
	0.1495			x	x	x	dissol		200 to 300
acetone	0.5996	x	x	dissol					200 to 300
	0.6000	x	x	dissol					200 to 300
ethyl acetate	0.6007	x	x	dissol					200 to 300
	0.5994	x	x	dissol					200 to 300

x = undissolved material remaining

dissol = sample totally dissolved

Final results

 

Solvent Class	Solvent	Solubility at 20 °C
Aliphatic hydrocarbon	n-heptane	3.7 g/L solution
Aromatic hydrocarbon	p-xyiene	120 to 150 g/L solvent
Halogenated hydrocarbon	1,2-dichloroethane	300 to 600 g/L solvent
Alcohol	methanol	25 to 30 g/L solvent
Ketone	acetone	200 to 300 g/L solvent
Ester	ethyl acetate	200 to 300 g/L solvent

Description of key information

Solubility at 20 °C in:
n-heptane: 3.7 g/L solution
p-xylene: 120 to 150 g/L solvent
1,2-dichloroethane: 300 to 600 g/L solvent
methanol: 25 to 30 g/L solvent
acetone: 200 to 300 g/L solvent
ethyl acetate: 200 to 300 g/L solvent

Additional information

Aliquots of n-heptane saturated with test item were analysed by a gas chromatographic method.

The direct addition method was used for p-xylene, 1,2-dichloroethane, methanol, acetone and ethyl acetate.