Registration Dossier
Registration Dossier
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EC number: 443-870-0 | CAS number: 163520-33-0
Endpoint summary
Administrative data
Description of key information
Additional information
The overall environmental fate profile indicates that the substance is of low persistence in the environment, Isoxadifen-ethyl is rapidly hydrolysed at environmentally relevant conditions to its free acid (DT50: 2.3 days at pH 7). A rapid degradation by hydrolysis is also demonstrated in the available studies on the degradation of the target substance in sediment and soil. The target compound, isoxadifen-ethyl, is quickly eliminated from both water body and sediment by hydrolysis to the free acid and further biodegradation of this hydrolysis product (DT50: 0.4 – 3.2 days at 12°C based on data obtained from water/sediment systems, aerobic conditions). Also in soil the biodegradation shows similar degradation times with DT50 values of 0.8 – 2.4 days at 12°C under aerobic conditions. Therefore, hydrolysis is expected to be an important process in the fate of the substance. The log Pow < 3.0 for the hydrolysis products, and < 4.5 for the target compound, indicates that the target substance and the products of hydrolysis have a low potential for bioaccumulation. An adsorption/desorption study according to OECD guideline 121 with the target compound resulted in a log Koc = 3.4, which shows a low adsorption potential to soil and sediment. Furthermore, the target compound has a low water solubility with 1.06 mg/L at 20 °C and pH 5.54 – 6.85. The photolysis in soil is not a relavant degradation pathway for the substance. The vapour pressure of the substance is very low (2.2E-6 Pa at 20 °C), thus the substance is considered not volatile. Therefore, any risk of long-range transport by or accumulation in the air is very unlikely, for the substance and it is concluded that the substance will not accumulate in air and will not be transported through the vapour phase into other environmental compartments in relevant amounts. Therefore, air is not a likely route of environmental exposure and no accumulation and subsequent deposition of the substance is to be expected.
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