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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Slags, ferronickel-manufg. /Electric Furnace Slag/ Converter Slag was tested for dermal sensitising properties according to the OECD Guidelines for Testing of Chemicals, number 429, “Skin Sensitisation: Local Lymph Node Assay” (adopted: July 22, 2010).

Based on the results of the preliminary test the test item was extracted according to ISO 10993-12 and assessed for sensitising properties at extract concentrations of 25 %, 50 % and 100 % (v/v).

The stimulation index at an extract concentration of 25% was1.1

The stimulation index at an extract concentration of 50% was1.2

The stimulation index at an extract concentration of 100% was1.1

At the daily clinical observation the animals did not show any visible clinical symptoms and no case of mortality were observed.

Species/strain: Mice, CBA/CaOlaHsd

Number of animals:20/main test

Vehicle: AOO (3+1(v/v) acetone/olive oil)

The EC3 value (derived by linear interpolation) could not be calculated as the stimulation indices of all concentrations were below 3. Consequently, according to OECD 429 ISO 10993-12: 2007 “Sample preparation and reference materials” and the criteria given in Annex I of Regulation (EC) 1272/2008 Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. Official Journal of the European Communities, L 353, 31.12.2008, the test item Slags, ferronickel-manufg. /Electric Furnace Slag/ Converter Slag, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser.


Migrated from Short description of key information:
The EC3 value (derived by linear interpolation) could not be calculated as the stimulation indices of all concentrations were below 3. Consequently, according to OECD 429 ISO 10993-12: 2007 “Sample preparation and reference materials” and the criteria given in Annex I of Regulation (EC) 1272/2008 Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. Official Journal of the European Communities, L 353, 31.12.2008, the test item Slags, ferronickel-manufg./Electric Furnace Slag/ Converter Slag, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser.
The substance contains Nickel metal, which is classified as skin sensitiser 1. However, it is bound in the matrix of the slags and it exists in a low concentration (<0.5% w/w), not sufficient for classification, if the substance were to be regarded as a mixture. However, the test results show that no skin sensitising properties occur.
The test was performed on a grade of slags, ferronickel-manufg. with a high content of Nickel, which is the most notorious substance in regards to sensitisation. Since no effects were observed, no grade of the substance should be classified or considered a sensitiser.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

According to ECHA Guidance Document R.7A, a chemical which fails to induce a positive response in LLNA testing most probably lacks the potential for respiratory allergy. Therefore, converter slag is not considered a respiratory allergen.


Migrated from Short description of key information:
According to ECHA Guidance Document R.7A, a chemical which fails to induce a positive response in LLNA testing most probably lacks the potential for respiratory allergy. Therefore, converter slag is not considered a respiratory allergen.

Justification for classification or non-classification

The EC3 value (derived by linear interpolation) could not be calculated as the stimulation indices of all concentrations were below 3. Consequently, according to OECD 429 ISO 10993-12: 2007 “Sample preparation and reference materials” and the criteria given in Annex I of Regulation (EC) 1272/2008 Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. Official Journal of the European Communities, L 353, 31.12.2008, the test item Slags, ferronickel-manufg./Electric Furnace Slag/ Converter Slag, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser. The substance contains Nickel metal, which is classified as skin sensitiser 1. However, it is bound in the matrix of the slags and it exists in a low concentration (<0.5% w/w), not sufficient for classification, if the substance were to be regarded as a mixture. However, the test results show that no skin sensitising properties occur.

It is advisable however, that in the SDS the presence of Nickel metal should be mentioned.