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EC number: 273-729-7
CAS number: 69012-29-9
By-product from the production of ferronickel from a complex ore. Consists primarily of oxides of aluminum, iron, magnesium and silicon.
30 rats in 6 chambers were exposed to 75 mg
Al2O3/m3 for 6 months (6h/day, 5d/wk). Average concentration measured by
dividing the weight of accumulated dust/filter/day by the volume of air
passed through the chamber/day
No mortalities up to 6 months after exposure initiation. Lungs
of rats exposed at 6 months contained foci of clustered alveoli with
well preserved swollen macrophages engorged with Al2O3 particles. No
abnormal proliferation of the macrophages. No alveolar proteinosis or
From this subchronic study a NOAEC of 75mg Al2O3/m3
can be established. Based on the typical aluminum oxide content of our
substance a NOAEC of 1250 mg Electrofurnace slag/m3and
7500mg Converter slag/m3 can be established, which makes the hazard from
the inhalation of ferronickel slags insignificant. Additionally,
granulometry results on ferronickel slags show that only about 6% of the
test item consists of particles with size less than 5 µm, which form the
majority of the tested substance (see also Endpoint 4.5 - Particle Size
Distribution). As a result there is an overestimation of risk due to
Ferronickel slags inhalation based on Aluminium Oxide results.
Nevertheless these results will be taken into account for long-term
inhalation risk assessment.
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