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EC number: 212-084-8
CAS number: 760-93-0
Mortality: No difference in survival between treated and untreated
Site / Lesion
Nasal Cavity /
Olfactory sensory epithelium /
Focal or multifocal fibrosis
No histopathological findings other than local findings in the
respiratory tract. Systemic histopathological effects, as for example in
the brain in females particularly at 2000 ppm and above in the
subchronic range finding study (Batelle, 1980), are absent in this 104
Body weight: Mean body weight gain was reduced in females at 500 ppm
resulting in 6 -11% lower body weights after week 73 and in males at
1000 ppm which were 5 -10 % lower than controls after week 81.
There was no treatment-related increase in tumour incidence.
In this104-week study
with groups of 50 animals each, male rats were treated with MMA vapour
by whole-body exposure to 500 or 1000 ppm while female rats were exposed
to 250 or 500 ppm.
The primary finding was
inflammation of rat nasal cavity as well as olfactory epithelial
degeneration at all exposure levels in male and female rats. For local
effects the LOAEC was 250 ppm in this study while a NOAEC could not be
In contrast to the 90 d
range finding study with histopathological changes in females at
exposures of 1000 ppm and above (Battelle, 1980), no other significant
histopathological changes were reported in male and female rats after
104-week exposures to MMA vapour in this study. Based on this a NOEC for
systemic effects of 500 ppm is derived.
and female rat body weights were lower at the 1000 ppm (5-10%) and 500
ppm (6-11%) exposure levels, respectively, presumably due to reduced
food consumption due to nasal irritation and damage of olfactory
epithelium. While food consumption was not recorded in this study this
association is confirmed by two other studies, the developmental
toxicity study with MMA with reduced food consumption and reduced body
weight gain at concentrations higher than 99 ppm (Solomon, 1993) and a
subchronic inhalation study with methacrylic acid where there was also
an association of irritative effects in the nose and reduced food
consumption and reduced body weight gain (BASF, 2008). Consequently,
reduced body weight gain, while clearly treatment-related - is
considered to be secondary to the local effects in the nose and not the
result of true systemic toxicity.
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