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EC number: 212-084-8 | CAS number: 760-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Repeated dose dermal irritation study, histopathology of skin only, study purpose was to investigate skin reactions of dilutions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Method: other: application on the shaved backs of mice , male ICR-mice, 8 animals/dose group
100 ul per mouse/day for a total of 9 treatment days - GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methacrylic acid
- EC Number:
- 201-204-4
- EC Name:
- Methacrylic acid
- Cas Number:
- 79-41-4
- Molecular formula:
- C4H6O2
- IUPAC Name:
- 2-methylprop-2-enoic acid
- Details on test material:
- purity approx. 100 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other:
- Sex:
- male
Administration / exposure
- Duration of treatment / exposure:
- 3 weeks
- Frequency of treatment:
- 3 time/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4 % aq. sol. of MAA and 4.8 - 19.2 % aqueous solution of methacrylic acid in acetone
Basis:
- No. of animals per sex per dose:
- 8 animals/dose group
- Control animals:
- other: yes (solvent)
- Details on study design:
- 100 ul per mouse/day for a total of 9 treatment days
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Description (incidence and severity):
- see results
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Details on results:
- With MAA as an aqueous solution of 4.8 % (= approx. 150 mg/kg) no skin irritation was observed after single or repeated dermal exposure up to 21 d (treatment interval 2-3 days, 9 exposures). When methacrylic acid was diluted in acetone and applied similarly, concentration-related irritation was observed. At 4.8 % in acetone, there was minimal irritation within the first 72 hours which progressed to slight after 21 d. Moderate to severe irritation was observed with 9.6 % (= approx. 300 mg/kg) and 19.3 % (= approx. 600 mg/kg) solutions with hyperplasia, hyperkeratosis, fibrosis, ulceration and necrosis. No clinical signs indicative of systemic toxicity were observed at any dose in any of the mice.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 600 mg/kg bw/day
- Sex:
- male
- Basis for effect level:
- other: (= 19.3 % / 2.24 M) Local irritation, but no clinical signs of systemic effects
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Dilutions of MAA in acetone and water show mild irritation at 4.8 % in a study in mice, in which dilutions of MAA were applied for 21 d in succession, while the effects are more pronounced at 9.6 % in acetone and progress to severe irritation at 19.2 % in acetone.
- Executive summary:
Dilutions of MAA in acetone and water show mild irritation at 4.8 % in a study in mice, in which dilutions of MAA were applied for 21 d in succession, while the effects are more pronounced at 9.6 % in acetone and progress to severe irritation at 19.2 % in acetone.
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